ABY-039 has been specifically designed to combine Affibody’s protein therapeutics platform (Affibody® molecules) and Albumod™ technology to achieve a long half-life, which, along with its small size provides the potential for less frequent, convenient, at-home subcutaneous administration.

Affibody Brief Summary The purpose of this first-in-human study is to investigate the safety and tolerability of ABY-039 after single and multiple doses in healthy volunteers.

ABY-039 kan bli ett fantastiskt läkemedel för behandling av en rad autoimmuna sjukdomar, säger Torbjörn Susanne Hallström, Krusenhofsvägen 292, 616 32 Åby, (51) B60K 37/00 (11) 537 (51) G07C 5/08 (11) 537 039 G08C 17/02 (21) 1350472-5 (22) 2013-04-15 därav (54) Monoklonala antikroppar till fibroblasttillväxtfaktor (73) Affibody AB, ABY-039 is a bivalent antibody-mimetic that targets the neonatal Fc receptor and that has shown potent lowering of plasma IgG titers and very long half-life in healthy volunteers in Phase 1. Its main competitor, efgartigimod, has recently demonstrated the benefit of IgG lowering in patients with myasthenia gravis in Phase 3. ABY-039 is a novel FcRn targeting agent, which has been specifically designed to utilize the strengths of Affibody’s technology platform to differentiate from competing antibody based approaches. A Study to Investigate the Safety, Tolerability and Pharmacokinetics of ABY-039 The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.

Fc receptor (FcRn). Affibody retained the rights to lead clinical development of. 27 mar 2019 Det svenska bolaget Affibody, ett företag med rötterna i KTH, har precis Detta går ut på att samutveckla läkemedelskandidaten ABY-039 för 15 Jun 2020 ABY-039 is a bivalent antibody-mimetic that targets the neonatal Fc receptor and that has shown potent lowering of plasma IgG titers and very 17 Dec 2014 Biparatopic molecules, comprising the two Affibody domains, were hence engineered to Cell 146, 873–887, 10.1016/j.cell.2011.08.039 (2011). in breast cancer metastases using the 111In-ABY-025 affibody molecule. 25 Apr 2019 Alexion forged two partnerships focused on treatments associated with the immune system: a deal with Affibody Ab to help develop ABY-039 Human IgG1.

15 Mar 2007 A radiolabeled anti-HER2 Affibody molecule (ZHER2:342) targets HER2- expressing xenografts with high selectivity and gives good imaging 11 Apr 2010 Affibody molecules are a class of engineered affinity proteins with proven potential for therapeutic, diagnostic and biotechnological applications 4.

Alexion Pharmaceuticals announced two big collaboration partnerships today. First, Alexion, headquartered in Boston, and Affibody AB, located in Solna, Sweden, signed a partnership deal to co-develop ABY-039 for Immunoglobulin G (IgG)-mediated autoimmune diseases.. ABY-039 is currently in Phase I development. It is a bivalent antibody-mimetic targeting the neonatal Fc receptor (FcRn) and …

Source: EvaluatePharma, company 19 May 2020 DUBLIN – Affibody AB is getting $10 million up front and up to $215.5 Inc. decided to terminate its interest in ABY-039 after a phase I trial. ABY-039, Affibody, Phase 1 (ongoing), Unknown. FcγR-targeting therapeutics. Valziflocept (SM101/SHP652), Baxalta/Shire/Takeda, Phase 2a (completed), ITP, 20 Mar 2019 The Affibody deal gives Alexion access to ABY-039, a therapy for rare Immunoglobulin G-mediated autoimmune diseases that's currently in 20 Mar 2019 #Alexion & #Affibody partner to develop ABY-039 vs IgG-mediated #autoimmune diseases Affibody to receive $25M upfront + up to $625M in 25 Nov 2020 eases with a molecule termed ABY-039 which is presumed to be Affibody peptides against FcRn have also shown promising results in vivo, development, ABY-039 is a bivalent antibody-mimetic that targets the neonatal.

Affibody: ClinicalTrials.gov Identifier: NCT03502954 Other Study ID Numbers: ABY-039-001 2017-002918-32 ( EudraCT Number ) First Posted: April 19, 2018 Key Record Dates: Last Update Posted: June 17, 2020 Last Verified: June 2020 Individual Participant Data …

Genenetech (Roche). Parvus Therapeutics. Navacim. Autoimmunitet (IBD, Celiak etc).

The trial is evaluating intravenous and subcutaneous ABY-039 has been specifically designed to combine Affibody’s protein therapeutics platform (Affibody ® molecules) and Albumod™ technology to achieve a long half-life, which, along with its small size provides the potential for less frequent, convenient, at-home subcutaneous administration. Det svenska bolaget Affibody, ett företag med rötterna i KTH, har precis ingått ett avtal med det amerikanska läkemedelsbolaget Alexion.
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ABY-039. VD har ordet. 3.

Phase I Trial of ABY-039 for Autoimmune Diseases Solna, Sweden, March 13, 2018.
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ABY-039 has been specifically designed to combine Affibody's protein therapeutics platform (Affibody molecules) and Albumod technology to achieve a long half-life, which, along with its small size

Affibody AB and Alexion Pharmaceuticals, Inc. (NASDAQ: ALXN) today announced a partnership to co-develop ABY-039 for rare Immunoglobulin G (IgG)-mediated autoimmune diseases. Swedish company Affibody has announced the termination of its ABY-039 (FcRn) program in rare autoimmune… To continue reading The Pharma Letter please login , subscribe or claim a 7 day free trial subscription and access exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space.

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Affibody Announces Termination of ABY-039 (FcRn) Program Solna, Sweden, June 15, 2020. Affibody AB (“Affibody”), a clinical stage biopharmaceutical company today announced the completion of

2020-02-26 Affibody has the option to co-promote ABY-039 in the U.S. and will lead clinical development for an undisclosed indication. “We believe there is significant opportunity to transform patient care with FcRn-targeted therapies and are thrilled to add a second clinical-stage anti-FcRn medicine to our pipeline with this collaboration,” said John Orloff, Executive Vice President and Head of R&D ABY-039 is designed to target the neonatal Fc receptor (FcRn), combining Affibody’s protein therapeutics platform (Affibody ® molecules) and Albumod™ technology to achieve a long half-life.

Affibody: ClinicalTrials.gov Identifier: NCT03502954 Other Study ID Numbers: ABY-039-001 2017-002918-32 ( EudraCT Number ) First Posted: April 19, 2018 Key Record Dates: Last Update Posted: June 17, 2020 Last Verified: June 2020 Individual Participant Data …

ABY-039.

ABY 039 is a Affibody has announced the completion of the ABY-039 Phase 1 trial, and the termination of the ABY-039 program due to tolerability observations that would limit the target product profile of subcutaneous high dose once monthly maintentance injections. Based on these observations Alexion has terminated the co-development agreement with Affibody. Affibody AB and Alexion Pharmaceuticals, Inc. (NASDAQ: ALXN) today announced a partnership to co-develop ABY-039 for rare Immunoglobulin G (IgG)-mediated autoimmune diseases. ABY-039 is designed to target the neonatal Fc receptor (FcRn), combining Affibody’s protein therapeutics platform (Affibody ® molecules) and Albumod™ technology to achieve a long half-life. Affibody moved ABY-039 into a phase 1 study in healthy volunteers last year to assess its safety, tolerability and pharmacokinetics.